Cell culture-based discovery of antiviral inhibitors and their mechanism of action

compound library screening, molecular virology, supporting the hit-to-lead optimisation process
 

Antiviral targets in complex with RNA and inhibitors

structural and functional characterization of viral enzymes and their interactions with each other, substrates, ligands and inhibitors
 

Target-directed discovery of antivirals

structure-based lead discovery for selected viruses that offer appropriate starting points, screening of compound libraries using enzymatic assays, optimization of activity and selectivity by structure-based design and medicinal chemistry
 

ADME-Tox and validation in animal models

proof-of-concept in animal models, Absorption, Distribution,
Metabolism, and Excretion (ADME)-tox studies
 

Exploitation and route-to-market

IP management, product development, interaction with European SMEs operating in biotechnology and/or pharmaceutical industry, dissemination
 

Coordination

Management will thus ensure that the project progresses smoothly with respect to the work plan in terms of scientific activities (including ethics aspects), that it has adequate financial and management follow-up procedures and that the communication amongst the Partners is maintained throughout the project.