Strategy

The project will focus its activities on three priority virus groups, responsible of major human viral diseases for which the development of drugs is considered essential: flaviviridae (Dengue), picornaviridae (enterovirus 71) and paramyxoviridae (RCV and hMPV). On the other hand, exploratory researches will be performed on other virus families that have the potential to cause epidemics, like the arenaviruses group, alphaviruses, bunyaviruses, coronaviruses and noroviruses .

The SILVER project contains 6 work packages.

A pipeline strategy gathering chemistry, virology, structural genomic and biology disciplines, has been developed to identify targets and their potential inhibitors. In a further stage, hits and leads will be designed including ADME-tox studies and relevant animal models assays to reach the Proof of Concept level. Multidisciplinary studies will be organised around each group of virus allowing a high efficiency in collaboration and results-oriented performance (WAVE concept).

The research leading to these results has received funding from the European Union Seventh Programme (FP7 2007/2013) under grant agreement n°260644-SILVER